Protein name:
    G1/S-specific cyclin-D2 ;
    
    Alternative:
    
    
    
 
    Organism:
        
        
        
        
        
        
    
        Human  (Homo sapiens).  
    
 
General Annotation
    Sub Unit:
    Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity.
    
 
    Function:
    Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
    
 
    
        
        Subcellular Location:
        
    
     
     
      Nucleus 
      
     
      Cytoplasm 
      
     
      Membrane 
      
    Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. 
  
    
 
    
    Protein Attributes:
    
    50:
    MELLCHEVDP |  VRRAVRDRNL |  LRDDRVLQNL |  LTIEERYLPQ |  CSYFKCVQKD |  
    
 
    100:
    IQPYMRRMVA |  TWMLEVCEEQ |  KCEEEVFPLA |  MNYLDRFLAG |  VPTPKSHLQL |  
    
 
    150:
    LGAVCMFLAS |  KLKETSPLTA |  EKLCIYTDNS |  IKPQELLEWE |  LVVLGKLKWN |  
    
 
    200:
    LAAVTPHDFI |  EHILRKLPQQ |  REKLSLIRKH |  AQTFIALCAT |  DFKFAMYPPS |  
    
 
    250:
    MIATGSVGAA |  ICGLQQDEEV |  SSLTCDALTE |  LLAKITNTDV |  DCLKACQEQI |  
    
 
    289:
    EAVLLNSLQQ |  YRQDQRDGSK |  SEDELDQAST |  PTDVRDIDL
    
 
      Vaild Sequence:
    
 
Related Databases
Uniprot:
 
 
    
        
        ELISA Kit
         
        
        CLIA Kit
         
        
        Polyclonal Antibody
         
        
        Monoclonal Antibody
         
        
        Protein
         
        
     
FOR
    
        
        Human
         
        
        Mouse
         
        
        Pig
         
        
        Bovine
         
        
        Chicken
         
        
        Rat
         
        
     
    
        ELISA Kit for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
    
    
 
    
        Protein for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
    
    
 
    
        Protein for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
    
    
 
    
        Protein for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
    
    
 
    
        Protein for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
    
    
 
    
        Protein for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
    
    
 
    
        Protein for Human G1/S-specific cyclin-D2
        
     
    
    
    
    
    
    
 
 
 
 
 
 
 
 
    R&D Technical Data
    
    
    
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    References
    
    
        
            
        
            
                1.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) 
                    
                    
                 
             
         
            
        
            
                2.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) 
                    
                    
                 
             
         
            
        
            
                3.
                
                    
                        
                        
                            Miyajima N. 
                        
                        
                        
                            Submitted (1993-03) to the EMBL/GenBank/DDBJ databases
                        
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) 
                    
                    
                    tissue :
                    
Bone marrow .  
             
         
            
        
            
                4.
                
                    
                        
                            "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." 
                        
                        
                            Kalnine N. 
                        ,
                            
Chen X. 
                        ,
                            
Rolfs A. 
                        ,
                            
Halleck A. 
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Hines L. 
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                        ,
                            
Phelan M. 
                        ,
                            
Farmer A. 
                        
                        
                        
                            Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
                        
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) 
                    
                    
                 
             
         
            
        
            
                5.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ARG-268 
                    
                    
                 
             
         
            
        
            
                6.
                
                    
                        
                            "Complete sequencing and characterization of 21,243 full-length human cDNAs." 
                        
                        
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                        ,
                            
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Otsuki T. 
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                              more...   
                             
                        
                        
                        
                            Nat. Genet.36:40-45(2004)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) 
                    
                    
                 
             
         
            
        
            
                7.
                
                    
                        
                            "The finished DNA sequence of human chromosome 12." 
                        
                        
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                              more...   
                             
                        
                        
                        
                            Nature440:346-351(2006)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 
                    
                    
                 
             
         
            
        
            
                8.
                
                    
                        
                        
                            Mural R.J. 
                        ,
                            
Istrail S. 
                        ,
                            
Sutton G.G. 
                        ,
                            
Florea L. 
                        ,
                            
Halpern A.L. 
                        ,
                            
Mobarry C.M. 
                        ,
                            
Lippert R. 
                        ,
                            
Walenz B. 
                        ,
                            
Shatkay H. 
                        ,
                            
Dew I. 
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Miller J.R. 
                        ,
                            
Flanigan M.J. 
                        ,
                            
Edwards N.J. 
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Bolanos R. 
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Fasulo D. 
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Halldorsson B.V. 
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Hannenhalli S. 
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                            Yooseph S. 
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                        ,
                            Venter J.C. 
                        
                             
                              more...   
                             
                        
                        
                            Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
                        
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 
                    
                    
                 
             
         
            
        
            
                9.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) 
                    
                    
                    tissue :
                    
Bone marrow . tissue :
                    
Uterus .  
             
         
            
        
            
                10.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-240 
                    
                    
                    tissue :
                    
Placenta .  
             
         
            
        
            
                11.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-140 (ISOFORM 2) 
                    
                    
                    tissue :
                    
Glioblastoma .  
             
         
            
        
            
                12.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for INTERACTION WITH CDK4;SUBCELLULAR LOCATION 
                    
                    
                 
             
         
            
        
            
                13.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for SUBCELLULAR LOCATION (ISOFORM 2);ALTERNATIVE SPLICING 
                    
                    
                 
             
         
            
        
            
                14.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for UBIQUITINATION BY SCF(FBXL2)